Sophie Manner
Studierektor
Expanding the scope of methyl xanthate esters - From Barton-McCombie reaction auxiliary to versatile protective group
Författare
Summary, in English
The methyl xanthate ester is presented as a versatile protective group for alcohols. Hydroxyl groups can easily be transformed into methyl xanthate esters by several methods and are commonly used as an auxiliary in the Barton-McCombie reaction. We show that these methyl xanthate esters can readily and chemoselectively be cleaved under mild conditions by the action of diethylenetriamine using microwave heating. This method is orthogonal to many common hydroxyl protective groups that can be introduced and cleaved in the presence of methyl xanthate ester.
Avdelning/ar
- Centrum för analys och syntes
Publiceringsår
2017
Språk
Engelska
Sidor
6329-6333
Publikation/Tidskrift/Serie
Tetrahedron
Volym
73
Issue
44
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Organic Chemistry
Nyckelord
- Alcohol protection
- Chemoselective
- Deprotection
- Diethylenetriamine
- Methyl xanthate ester
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0040-4020