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Sophie Manner

Studierektor

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Spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics. Synthesis and toxicity evaluation in breast cancer cell lines.

Författare

  • Sophie Manner
  • Viveca Oltner
  • Stina Oredsson
  • Ulf Ellervik
  • Torbjörn Frejd

Summary, in English

Paclitaxel is one of the most important anti-cancer agents introduced during the last 20 years. However, the use of paclitaxel is limited by undesirable side effects as well as the development of drug resistance. Here, we report a synthetic strategy towards spiro-bicyclo[2.2.2]octane derivatives, which includes double Michael addition and ring-closing metathesis as key synthetic steps. This strategy was used to synthesize a series of spiro-bicyclic compounds designed to be paclitaxel mimetics, which were evaluated in human breast-derived cell lines. One of these paclitaxel mimetics showed toxicity, although at higher concentrations than paclitaxel itself. In addition, two other spiro-bicyclic compounds, lacking the paclitaxel side chain, showed toxicity.

Avdelning/ar

  • Centrum för analys och syntes
  • Functional zoology
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publiceringsår

2013

Språk

Engelska

Sidor

7134-7144

Publikation/Tidskrift/Serie

Organic and Biomolecular Chemistry

Volym

11

Issue

41

Dokumenttyp

Artikel i tidskrift

Förlag

Royal Society of Chemistry

Ämne

  • Zoology
  • Chemical Sciences

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1477-0539