KILU Seminar: Recent advances in C-H hydro-xylation using Cu, H2O2 and directing groups

At the KILU-seminars preeminent scientists present their work in a chemistry wide setting. The seminar series provides an opportunity to learn about exciting current research. 
In addition, it is an opportunity to meet, exchange ideas and discuss science with colleagues from all around KILU and beyond.

Speaker
Professor Isaac Garcia-Bosch, Department of Chemistry, Carnegie Mellon University.

Topic
Recent advances in C-H hydroxylation using Cu, H²O² and directing groups

Cu-dependent metalloenzymes catalyze a wide array of oxidative transformations using O2 as oxidant under mild conditions. These include the hydroxylation of challenging organic substrates (e.g., oxidation of methane to methanol in particulate methane monooxygenase) and the regio- and enantioselective hydroxylation of complex molecules (e.g. benzylic hydroxylation of dopamine to noradrenaline in dopamine-beta-monooxygenase).
Lytic polysaccharide monooxygenases enzymes (LPMOs) promote the C-H hydroxylation and subsequent cleavage of the polysaccharide chains found in natural materials such as cellulose or chitin. Recent reports on the reactivity of LPMOs suggest that, instead of O2, these Cu-dependent metalloenzymes utilize H2O2 as oxidant.
In 2015, our research lab reported that the catalytic hydroxylation of strong C-H bonds (e.g. cyclohexane) using Cu and H2O2 proceeded via formation of non-selective Fenton-like oxidants (hydroxyl and hydroperoxyl radicals). To achieve regioselectivity, LPMOs bind the organic substrate before exposing the Cu center to the oxidant, a reaction that leads to the formation of highly organized ternary complex prior to substrate hydroxylation (i.e., metal-substrate-oxidant adduct).
In this talk, we will present our recent findings on the utilization of Cu, H2O2, and directing groups to promote regioselective C-H hydroxylation.

Time and place
June 4 at 15:15-16:00 in lecture hall B at Kemicentrum.

Coffee and cake is served from 15:00 outside lecture hall B - on a first come, first serve basis.

Welcome!

Ola, Marie and Mikael