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Sophie Manner

Director of studies

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Molecular Wipes: Application to Epidemic Keratoconjuctivitis

Author

  • Karolina Aplander
  • Marko Marttila
  • Sophie Manner
  • Niklas Arnberg
  • Olov Sterner
  • Ulf Ellervik

Summary, in English

Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing molecules can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC50 = 0.9 mu M) and Ad infectivity (IC50 = 0.7 mu M). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC.

Department/s

  • Centre for Analysis and Synthesis

Publishing year

2011

Language

English

Pages

6670-6675

Publication/Series

Journal of Medicinal Chemistry

Volume

54

Issue

19

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Medicinal Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1520-4804