Sophie Manner
Director of studies
Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant
Author
Summary, in English
A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.
Department/s
- Centre for Analysis and Synthesis
Publishing year
2019
Language
English
Pages
55-58
Publication/Series
Natural Product Communications
Volume
14
Issue
1
Document type
Journal article
Publisher
Natural Products Inc
Topic
- Pharmaceutical Sciences
- Microbiology
Keywords
- Bolivia
- Cytotoxicity
- Giardia lamblia
- Hyptis brevipes
- Leishmania spp
- Plasmodium falciparum
- Tacana
- Trypanosoma cruzi
Status
Published
ISBN/ISSN/Other
- ISSN: 1934-578X