Sophie Manner
Director of studies
Simple carbohydrate derivatives diminish the formation of biofilm of the pathogenic yeast candida albicans
Author
Summary, in English
The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. albicans from yeast-form cells to cells forming hyphae. These compounds, benzyl α-l-fucopyranoside and benzyl β-d-xylopyranoside, inhibit the hyphae formation and adhesion of C. albicans to a polystyrene surface, resulting in a reduced biofilm formation. The addition of cAMP to cells treated with α-l-fucopyranoside restored the yeast-hyphae switch and the biofilm level to that of the untreated control. In the β-d-xylopyranoside treated cells, the biofilm level was only partially restored by the addition of cAMP, and these cells remained mainly as yeast-form cells.
Department/s
- Centre for Analysis and Synthesis
- Molecular Cell Biology
Publishing year
2020
Language
English
Publication/Series
Antibiotics
Volume
9
Issue
1
Document type
Journal article
Publisher
MDPI AG
Topic
- Biochemistry and Molecular Biology
- Pharmaceutical Sciences
Keywords
- Biofilm
- Candida albicans
- Fucoside
- Xyloside
Status
Published
ISBN/ISSN/Other
- ISSN: 2079-6382