Sophie Manner
Director of studies
Chemistry of xylopyranosides.
Author
Summary, in English
Xylose is one of the few monosaccharidic building blocks that are used by mammalian cells. In comparison with other monosaccharides, xylose is rather unusual and, so far, only found in two different mammalian structures, i.e. in the Notch receptor and as the linker between protein and glycosaminoglycan (GAG) chains in proteoglycans. Interestingly, simple soluble xylopyranosides can not only initiate the biosynthesis of soluble GAG chains but also function as inhibitors of important enzymes in the biosynthesis of proteoglycans. Furthermore, xylose is a major constituent of hemicellulosic xylans and thus one of the most abundant carbohydrates on Earth. Altogether, this has spurred a strong interest in xylose chemistry. The scope of this review is to describe synthesis of xylopyranosyl donors, as well as protective group chemistry, modifications, and conformational analysis of xylose.
Department/s
- Centre for Analysis and Synthesis
- Biochemistry and Structural Biology
Publishing year
2015
Language
English
Pages
65-88
Publication/Series
Carbohydrate Research
Volume
418
Document type
Journal article review
Publisher
Elsevier
Topic
- Biochemistry and Molecular Biology
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-426X