Title: “Plants in the service of humanity – from stone age tools to CRISPR"”

Time: 12:15
Place: Zoom - https://lu-se.zoom.us/j/3524380649

This lecture is to celebrate the Day of Chemistry (for more information see here, in Swedish).

Abstract

Cultivated plants have served humanity for thousands of years. Important steps in the domestication process of plants with a specific focus on barley will be highlighted in the lecture.

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Tid: 17:15
Plats: Zoom länk https://lu-se.zoom.us/j/64440371463

Dagordning:

1. Öppnande av mötet

2. Val av ordförande, sekreterare och justerare för mötet

3. Fråga om mötet blivit behörigt utlyst

4. Verksamhetsberättelse för 2019

5. Kassörens bekännelse

6. Revisionsberättelse för 2019

7. Fråga om ansvarsfrihet för styrelsen

8. Val av styrelsemedlemmar

Petter Persson - Ordf. - nyval

Martin Trulsson - Sekreterare - omval

Mats Hansson - Kassör - omval

Magnus Ehinger - Ledamot - omval

Nitsa Kiriakidou Kazemifar - Ledamot - omval

Daniel Strand - Ledamot - omval

Sophie Manner - Ledamot - nyval

Joakim Stenhammar - Ledamot - nyval

Peter Spégel - Ledamot - nyval

Magdalena Tasic - Sexmästare - omval

Yong Li - Sexmästare - omval

Niels Koning - Sexmästare - omval

Niklas Warlin - Sexmästare - omval

Stephanie Jephthah - Sexmästare - omval

Weihua Lin - Sexmästare - omval

9. Val av revisorer

Lars Ivar Elding - omval

Folk Tjerneld - omval

10. Val av valberedning

Cecilia Emanuelsson - omval

Ebbe Nordlander - omval

11. Fastställande av medlemsavgift

12. Övriga frågor

13. Avslutande av årsmötet 

Titel: “Hur man river ett kärnkraftverk”

Tid: 12:15
Plats: Sal B, Kemicentrum, Naturvetarvägen 14

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Titel: “Bigger on the inside – Metallorganiska ramverksföreningar från topologi till tillämpningar”

Tid: 12:15
Plats: Sal B, Kemicentrum, Naturvetarvägen 14

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Titel: “Li-jonbatterier – vår räddning, eller ett framtida miljö- och resursproblem?”

Tid: 12:15
Plats: Sal B, Kemicentrum, Naturvetarvägen 14

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Titel: “Hur utses Nobelpristagare?”

Tid: 12:15
Plats: Sal B, Kemicentrum, Naturvetarvägen 14

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Title: “PNA-programmed self-assemblies for responsive systems”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Keywords

Chemical biology, Self-assembly, cooperative interactions, PNA, DNA

Abstract

The programmable nature of nucleic acid hybridization has inspired a number of applications beyond their natural function in heredity.  Peptide Nucleic Acids (PNA) are endowed with attractive properties for this endeavor as they are more robust and form more stable duplex than their natural counter parts. Several applications from our laboratory to encode and program self-assemblies of small molecules, template chemical reactions or display multimeric ligands will be presented.

References:  

1. PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions, S. Barluenga, N. Winssinger,  Acc. Chem. Res. 2015, 48, 1319-1331

2. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules, Chem. Sci., 2015, 6, 739-744.

3. Identification of Covalent Bromodomain Binders from DNA Display of Small Molecules, Angew. Chem. Int. Ed. 2015, 54, 6057-61.

4. Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization, T. Machida, S. Dutt, N. Winssinger,Angew. Chem. Int. Ed. 2016, 55, 8595-8.

5. Nucleic-acid templated chemical reaction in a live vertebrate, L. Holtzer, I. Oleinich, M. Anzola, K. K. Sadhu, M., E. Lindberg, Gonzalez-Gaitan, N. Winssinger, ACS Central Science,2016,2, 394-400.

6. Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity, D. Chang, E. Lindberg, N. Winssinger, J. Am. Chem. Soc. 2017, 139, 1444-1447.

7. Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells, T. Machida, A. Novoa, E. Gillon, S. Zheng, J. Claudinon, T. Eierhoff, A. Imberty, W. Römer, N. Winssinger Angew. Chem. Int. Ed. 2017, 56, 6762-6766.

8. Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection, J. Sayers, R.J. Payne, N. Winssinger, Chem. Sci.2018, 9, 896-903.

9. Luciferase-induced photoreductive uncaging of small-molecule effectors, E. Lindberg, S. Angerani, M. Anzola, N. Winssinger, Nature Commun. 2018, 9, 3539

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Titel: “Falskt, oäkta och helt underbart – industrimatens ärorika historia”

Tid: 18:00
Plats: Sal C, Kemicentrum, Naturvetarvägen 14

Sammanfattning

Det började redan i mitten på 1800-talet. Kemister och ingenjörer intresserade sig allt mer för livsmedel. Förutom att försöka förstå vad som händer när vi tillreder och äter, uppfann de helt nya sätt att producera livsmedel. Dessutom gjorde de mat av sådant som tidigare betraktats som avfall. Bullrande maskiner, syntetiska kemikalier och storskalighet äntrade matens värld. Det ledde inte bara till en förändring av vår matkultur utan också till en hätsk debatt som rasar än idag. Föredraget gör ett par nedslag i den industriella livsmedelsproduktionens fascinerande historia. Vi får bland annat svaret på hur Gustaf de Laval höll på att ruinera sig på fuskmjölk, varför Frankrike egentligen är den främsta margarinnationen och vem som var tidernas ondskefullaste livsmedelskemist.

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Titel: “Himmelsk kemi och stjärnors födelser”

Tid: 18:00
Plats: Sal C, Kemicentrum, Naturvetarvägen 14

Sammanfattning

När en stjärna föds faller partiklar samman i ett gravitationsfält varvid lägesenergi omvandlas till kinetisk energi. För att processen ska fortsätta effektivt måste en del kinetisk energi föras bort, vilket kan ske genom utsändande av elektromagnetisk strålning. Molekyler är effektiva strålare och det är därför viktigt att veta vilka molekyler som finns i den interstellära rymden och hur de bildas och förstörs. Den vanligaste interstellära molekylen är H2. Dess bildningshastighet beror på hur fort väteatomer diffunderar på små istäckta stoftkorn. I föredraget ger jag först bakgrunden till varför och sedan hur vi arbetar teoretiskt med att förstå de experimentella resultat som finns vid ca 10 K och innefattar intressanta isotopeffekter. Detta ger insikter inte bara i astrokemi utan även i fundamentala aspekter av kemin.

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Titel: “Jörgen Lehmann - En man som gjorde skillnad”

Tid: 18:00
Plats: Sal C, Kemicentrum, Naturvetarvägen 14

Sammanfattning

Idag är det få som känner till eller minns Jörgen Lehmann (1898-1989). Det kan tyckas märkligt eftersom han forskargärning resulterade i läkemedel som räddade tusen och åter tusen människor från tuberkulos och hjärt- och kärlsjukdomar. Han växte upp i Lund, gick på Spyken, läste medicin och kemi och disputerade under den legendariske Torsten Thunberg. Hans viktigaste forskningsinsatser utförde han i Göteborg där han var chef för en ny typ av verksamhet, ett centrallaboratorium. Under nära 40 år var han konsult åt Malmöbaserade Ferrosan, företaget som tillverkade och saluförde hans två banbrytande läkemedel, para-amnosalicylsyra och dikumarol. Som upptäckare av det första läkemedlet mot den fruktade tuberkulosen torde ett Nobelpris vara inom räckhåll. Så var också fallet, Jörgen Lehmann var nominerad flera gånger. Av skäl som varit dolda i arkiv och personers minne under lång tid blev det aldrig något erkännande i form av ett Nobelpris. Detta erkännande fick däremot Salman Waksman som i stort sett samtidigt var involverad i upptäckten av streptomycin. Kvällens föredrag kommer att avhandla Jörgen Lehmanns liv och gärningar samt diskutera skälen till det uteblivna Nobelpriset.

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Title: “Affinity selection from phage display libraries: strategies for exploring rugged fitness landscapes”

Sir Gregory P. Winter

University of Cambridge, UK

Time: 15:15
Place: Medicon Village Hörsal (Auditorium)

Take this opportunity and come and listen to Smith and Winter telling about their discoveries that awarded them the Nobel Prize.

Welcome!

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Title: “XFELs as molecular movie cameras”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Abstract

X-ray Free electron Lasers (XFELs) are revolutionizing the experimental capabilities in physical chemistry, biology, and condensed matter physics. At the same time, they also pose new challenges for the experimenters. Unlike synchrotrons, each X-ray pulse is unique in the sense that wavelength, wavelength distribution and intensity may vary from shot to shot, which has implications for experiment design, detectors, data handling, and data rates, which may reach several 10s of TB per experiment. Here I will discuss some examples of our experience from 8 years of hard X-ray XFEL experiments. A common theme in our work has been tracking ultrafast energy and charge transfer in solvated metal complexes and the interaction between solute and solvent. An example is shown in the figure [nat. comm. 2016, DOI: 10.1038/ncomms13678].

The efficiency, selectivity and rate of chemical reactions depend critically on the reaction environment. Solvation, the local organization of the solvent molecules around a solute, has a central role in the description of condensed phase chemical properties. Through XFEL experiments, we could track the sub picosecond light-induced motion of a photocatalytically active molecule and the structural response of the solvent to the changes in the molecular structure, shedding light on the atomistic mechanistic processes of solvation. Recently, we have been able to track coherent wave packet dynamics in both excited and ground state molecular systems, which may be the closest we have come to making real molecular movies.

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Title: “Panbio-electronics”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Abstract

Recent decades have seen the rise of a range of tools and technologies for interfacing technological and biological systems. There has been a consistent focus on animal and mammalian applications, particularly relating to neuroscience, and organic electronics have emerged as an ideal component in these applications. However, we have recently shown that organic electronics can also be applied to augment plant systems, brining decades of anthropocentric R&D to the plant kingdom. In this talk, I will introduce our recent advances and results in animal-focused and plant-focused “panbio-electronics”.

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Title: “The amyloid β peptide in Alzheimer´s disease: molecular interactions and structure conversions studied by chemical and biophysical methods ”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Abstract

The amyloid β (Aβ) peptide consists of 39-43 residues and is the major component of the neuritic plaques in the brains of Alzheimer's disease (AD) patients. It is possible to study the peptide self-aggregation process (“amyloid formation”, structures and kinetics) using biophysical methods such as NMR, fluorescence or CD spectroscopy. The interactions of Ab with small molecules, or metal ions such as Zn(II) or Cu(II), that modulate the aggregation process can be studied in semi-stationary states by these methods (1). Kinetic effects on the amyloid formation process can be followed by fluorescence, after labeling the material rich in β-structure by the amyloid-specific dye Thioflavin T. The β-hairpin structure of the peptide with a mainly unstructured N-terminus appears to be a basic unit for formation of the larger amyloid structures associated with insoluble fibrils. Smaller oligomeric peptide aggregates, possibly the major cell toxic agents, can be studied by Soft Ionization Mass Spectrometry. Fluorescence Correlation Spectroscopy (FCS) shows the heterogeneity of the aggregation process of ThT-labeled Aβ in terms of time dependent amyloid aggregate sizes, on a single particle level (2). Modulation of the amyloid formation by Zn(II) or Cu(II) ions binding to specific residues in the N-terminus of the Aβ peptide can be followed by FCS, showing changes in structures as well as kinetics for the aggregation process. Understanding the basic properties, molecular interactions and reactions of the major participants in the chemical processes leading to AD gives a firm basis for the future development of agents that may be used in therapies against AD (3,4).

References:

1. Abelein, A., Gräslund, A. and Danielsson, J. Zinc as a chaperone-mimicking agent for retardation of amyloid β peptide fibril formation. Proc. Nat. Acad. Sci. US 112 (2015) 5407-5412.

2. Tiiman, A., Jarvet, J., Gräslund, A. and Vukojevic, V. Heterogeneity and intermediates turnover during amyloid-β (Aβ) peptide aggregation studied by fluorescence correlation spectroscopy. Biochemistry 54 (2015) 7203-7211.

3. Luo, J., Wärmländer, K.T.S., Gräslund, A. and Abrahams, J.P. Cross interactions between the Alzheimer disease amyloid-β peptide and other amyloid proteins: a further aspect of the amyloid cascade hypothesis. J. Biol. Chem. 291 (2016) 16485-16493.

4. Wallin, C., Luo, J., Jarvet, J., Wärmländer, K.T.S. and Gräslund, A. The amyloid β peptide in amyloid formation processes: interactions with blood proteins and naturally occurring metal ions. Israel J. Chem. 57 (SI) (2017) 674-685.

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Title: “Assembling responsive nanoparticles”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Abstract

Self-assembly is not only the key construction principle that nature uses so successfully to fabricate its complex molecular machinery, it has also fascinated colloid and materials scientists for decades. Traditional self-assembled materials based on colloidal building blocks suffer from the fact that the emerging structures are often polydisperse and irregular. This has led to a number of exciting developments in order to overcome these deficiencies, such as the construction of more complex colloidal building blocks that allow for the incorporation of directional interactions, a transfer of concepts such as specificity and molecular recognition from supramolecular chemistry to the colloid world, and the use of directed self-assembly. In this seminar I will describe the use of responsive nanoparticles such as thermo- or pH-sensitive microgels as ideal building blocks to investigate the relationship between interactions and self-assembled structures. These particles are not only attractive model systems for basic research, but also of considerable technological importance to materials science and nanotechnology for the fabrication of nanostructured responsive or smart organic-inorganic hybrid materials. The combination of nanoscale inorganic moieties with organic polymers allows us to create materials with enhanced or even completely new properties, and I will show that we can design, synthesize and assemble functionalized responsive nanoparticles in order to make adaptive polymer-colloid nanomaterials with tailored optical, magnetic and mechanical properties.

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Title: “Perstorp – Innovation in time”

Time: 18:00
Place: Hall C, Chemical Center, Naturvetarvägen 14

Abstract

Perstorp AB has always been innovative company through the history starting with bio refinery for more than 135 years ago.  Both material and chemicals are part of the rich history. Everyone in Nordic countries remember Perstorp Ättika, Perstorp platta and Pergo and  quite of few chemists remember Formox process or Isolit, first plastic in Nordic countries. Now is the company one of the world leader in Specialty Chemicals business. What that means for the Innovation? How  the future might become for Perstorp? These are some questions I am going try to answer in the presentation.

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Title:“The science that gave me a Nobel Prize and the science that didn't”

Time: 17:30
Place: Kårhusets Aula (Auditorium)

Honorary Professor Jacques Dubochet has, together with Joachim Frank and Richard Henderson, been awarded the Nobel Prize in Chemistry 2017 "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution".

By rapidly cooling water, vitrifying the water instead of crystalizing it, Dubochet opened up for the possibilities of studying aqueous systems (including biological material such as membranes, proteins, and other biomolecules) using cryo-electron microscopy (cryo-EM).

Take this opportunity and come and listen to Dubochets telling about his discovery that awarded him the Nobel Prize as well as other discoveries that didn't.

Welcome!

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Titel: "Torbern Bergman: Vad gjorde kemisterna i Uppsala under 1700-talet?"

Dag:Torsdagen den 23:e November
Tid:18:00
Plats:Sal C, Kemicentrum, Naturvetarvägen 14

Sammanfattning

Utgående från Torbern Bergman som representant för svensk kemi under 1700-talet kommer jag att tala om vad kemisterna i Sverige och i Uppsala i synnerhet gjorde under 1700-talet. Vilka frågor intresserade dem, och varför? Hur försökte man lösa, både praktiskt och teoretiskt de problem man ställdes inför, och varför kemin blev en så stor vetenskap i Sverige under 1700-talet?

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Title:  "Reflections on the biointerface: Structure, interactions and processes"

Day:Thursday October 19th
Time:18:00
Place:Hall C, Chemical Center, Naturvetarvägen 14

Abstract

Biological membranes do not only occur as planar bilayer structures, but bilayers have also been shown to, depending on the lipid composition, curve into intriguing 3D structures. In fact the important role of curvature of lipid membranes have been increasingly been recognized. Understanding biological implications of such curved lipid interfaces as well as exploiting their full potential in applications, for e.g. drug delivery and other biomedical applications, poses a challenge that requires the development of novel, well-defined and versatile model system. We will discuss how this can be achieved by the supporting surface topology, e.g. vertical nano-wire arrays, or by changing the lipid composition or by introducing components, e.g. responsive particles, which can alter the curvature as a response to the environment. We will discuss how the lipid self-assembly structure can be change in desired way by adding a particular type of lipolytic enzymes. Here the (oil) triglyceride aqueous interface is important also for other processes like emulsification. Our results show that uptake of water in the triolein phase can occur and this can be affected by the presence of lipolytic enzymes.

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Title:  "Asymmetric Autocatalysis and the Origin of Homochirality"

Day:Monday October 30th
Time:18:00
Place:Hall C, Chemical Center, Naturvetarvägen 14

Abstract

Asymmetric autocatalysis is a reaction in which chiral product acts as a chiral catalyst for its own formation. We found asymmetric autocatalysis of pyrimidyl alkanol with significant amplification of ee in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde. Starting from pyrimidyl alkanol with extremely low ee as asymmetric autocatalyst, pyrimidyl alkanol with >99.5% ee was formed. By using asymmetric autocatalysis, the origin of homochirality has been examined. It was found that chiral inorganic crystals such as quartz, chiral isotopomers, chiral crystals composed of achiral organic compounds, circularly polarized light (CPL), enantiotopic face of achiral mineral, i.e., gypsum, act as chiral triggers in asymmetric autocatalysis to afford the product with high ee of the corresponding absolute configuration with those of chiral triggers. Absolute asymmetric synthesis without the intervention of any chiral factor has also been realized by asymmetric autocatalysis.

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Titel:  "Snacksindustrin och dess smaksättningssystem"

Dag:Tisdag den 23:e
Tid:18:00
Plats:Café Ester, Kemicentrum

Kvällens meny

Förrätt:
Snacksmarknaden och hur snacks produceras

Huvudrätt:
The creation of a seasoning
 
Efterrätt:
Framtiden

Till kaffet:
praktiska doftövningar

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Title:  "How perturbing the early life microbiome with antibiotics leads to long-term consequences"

Day:Monday May 8th
Time:18:00
Place:Hall C, Kemicentrum

Abstract

A central feature of mammalian development across an evolutionary timeframe is the high fidelity intergenerational transfer of resident microbes. Yet the developing microbiome, crucial in the early life time-window, has limited resilience. We show that early life antibiotic exposures can alter microbiota development with both metabolic and immunological consequences. This work highlights the importance of early events in shaping the microbiome of developing animals, with effects that may be relevant beyond the current generation.

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Title:  "Physical chemistry of skin - Relating molecular characteristics to macroscopic material properties"

Day:Thursday April 20th
Time:18:00
Place:Hall C, Kemicentrum

Abstract

The outer layer of human skin, stratum corneum, makes up a large interfacial barrier film that protects the body from desiccation and uptake of hazardous chemicals. The healthy skin has low very permeability to most molecules. It is also soft and pliable and it tolerates deformation. Taken together, the stratum corneum fulfills a number of essentially different requirements, and its special material properties can be related to the organization and dynamics in its molecular components, which are mainly lipids and keratin proteins.

In this talk I will discuss how stratum corneum can respond on a molecular level to changes in its environment and when it is exposed to solvents or other small molecules. The molecular effects will then be related to changes in the macroscopic properties of barrier function and swelling.

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