One project concerns the synthesis of receptors designed to recognize biomolecules. Mimicking Nature's recognition molecules by de novo synthesis of small and specific receptors would greatly simplify the study of recognition events in aqueous solution, thus complementing studies of e.g. carbohydrate-binding proteins. A second project concerns the synthesis of ligands for the galectins, a family of 14 mammalian lectins recognizing ß-D-galactose- containing glycoconjugates, playing critical roles in inflammation and cancer. Furthermore, chemistry for optimizing biocompatibility, mechanical stability, and signal properties of neural interfaces are developed. Finally, a medicinal chemistry project exploiting fragment-based design and screening is aiming at developing selective and efficient inhibitors of dihydrooretate dehydrogenase (DHODH), a newly characterized target protein for Malaria.
Synthetic biomimetic receptors
Chemistry and biology of galectin proteins
Design and synthesis of inhibitors of dihydrooretate dehydrogenase (DHODH), a newly characterized target protein for Malaria.
Chemistry of neural interfaces for CNS recording and stimulation