Ricardo Gaspar: Protein-Lipid Coaggregation: The role of ganglioside lipids in amyloid formation
Plats: Kemicentrum, Lecture hall F
A seminar by PhD Student Ricardo Gaspar, Physical Chemistry, Lund University.
We have recently reported that the underlying aggregation mechanism of α-synuclein (α-syn) is dominated by an autocatalytic secondary process at mildly acidic pH, solution conditions mimicking those in endosomes and other specific organelles. Recent experiments were performed to identify the nature of these secondary processes, distinguishing between fragmentation of fibrils and nucleation of monomer on the surface of existing aggregates.
In amyloid plaques, associated with several amyloidogenic diseases, tightly associated lipids have been identified. We explore how lipid membranes interfere with the aggregation of α-syn for different lipid systems, and investigate lipid-protein co-aggregation.