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Peter Kasson: Protein-membrane interactions and membrane organization in enveloped viral entry

Seminarium

Tid: 2019-02-15 10:30 till: 11:15
Plats: Kemicentrum, Lecture hall F
Kontakt: peter [dot] jonsson [at] fkem1 [dot] lu [dot] se
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Seminar by Peter Kasson, Senior Lecturer at Department of Cell and Molecular Biology, Molecular Biophysics, Uppsala University.

Abstract

Enveloped viruses infect cells by binding to and fusing with cellular membranes.  We have shown that the spatial organization of these interacting membranes can be key to infectious outcomes.  Cholesterol content is key to the infectivity of many viruses; we show for influenza that it plays an unexpected molecular role in organizing membrane components.  We also use single-virus fusion kinetics as a window into the mechanisms of infection, identifying off-pathway states that are targets for antivirals and disentangling the roles of viral binding, protein activation, and membrane bending in viral entry.

 

Link to Dr Kasson's web page (opens in new window): kasson lab