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Martin Malmsten: Interplay between amphiphilic peptides and nanoparticles for selective membrane destabilization and antimicrobial effects

Seminarium

Tid: 2019-10-28 14:15 till: 15:00
Plats: Kemicentrum, Lecture hall F
Kontakt: martin [dot] malmsten [at] fkem1 [dot] lu [dot] se
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A Physical Chemistry seminar by Professor Martin Malmsten, Physical Chemistry, Lund University, and Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

 

Abstract

As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are currently attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Until now, however, much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Here, nanoparticles may provide opportunities, e.g., for controlling peptide release, for reducing infection-related AMP degradation, or for increasing bioavailability. In addition, numerous nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects of such mixed systems as antimicrobials have been observed. The mechanistic origin of these effects are poorly understood that present, however, precluding rational design of mixed nanoparticle/AMP antimicrobials and nanoparticulate delivery systems for AMPs. Addressing this, membrane interactions and antimicrobial effects of a series of nanomaterials are outlined, particularly in combination with AMPs, including (i) nanoparticles as passive containers for AMPs, (ii) surface active nanoparticles and relation to peptide loading, (iii) AMP-nanoparticle co-aggregation for infection confinement, and (iv) combinations of AMPs with active nanoparticles, e.g., within the contexts of UV-induced ROS generation and antimicrobial effects.

Figure 1. Nanoparticulate drug delivery systems provide various advantages for antimicrobial peptides.
Figure 1. Nanoparticulate drug delivery systems provide various advantages for antimicrobial peptides.

 

[1] R. Nordström, R., et al. J. Colloid Interface Sci. 2018, 513, 141.

[2] S. Singh, et al., ACS Appl. Mater. Interfaces 2017, 9, 40094.

[3] K. Braun, et al. J. Colloid Interface Sci. 2016, 475, 161.

[4] S. Malekkhaiat Häffner, et al. ACS Appl. Mater. Interfaces 2019, 11, 15389.

 

M. Malmsten1,2

1Department of Pharmacy, University of Copenhagen, DK-2100 Copenhagen, Denmark

2Physical Chemistry 1, University of Lund, SE-221 00 Lund, Sweden

Presenting author email: martin [dot] malmsten [at] sund [dot] ku [dot] dk