"Asymmetric Autocatalysis and the Origin of Homochirality"
Plats:Hall C, Chemical Center, Naturvetarvägen 14
Public lecture at the Chemical Society in Lund by
Tokyo University of Science, Japan
Professor of applied chemistry
Title: "Asymmetric Autocatalysis and the Origin of Homochirality"
Day: Monday October 30th
Place: Hall C, Chemical Center, Naturvetarvägen 14
Asymmetric autocatalysis is a reaction in which chiral product acts as a chiral catalyst for its own formation. We found asymmetric autocatalysis of pyrimidyl alkanol with significant amplification of ee in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde. Starting from pyrimidyl alkanol with extremely low ee as asymmetric autocatalyst, pyrimidyl alkanol with >99.5% ee was formed. By using asymmetric autocatalysis, the origin of homochirality has been examined. It was found that chiral inorganic crystals such as quartz, chiral isotopomers, chiral crystals composed of achiral organic compounds, circularly polarized light (CPL), enantiotopic face of achiral mineral, i.e., gypsum, act as chiral triggers in asymmetric autocatalysis to afford the product with high ee of the corresponding absolute configuration with those of chiral triggers. Absolute asymmetric synthesis without the intervention of any chiral factor has also been realized by asymmetric autocatalysis.
The lecture is open to the public and will be held in english.
After the lecture there will be an informal reception at the Centre for Analysis and Synthesis (CAS), where you can meet the lecturer and the other attendants. Pea soup with punsch and pancakes (50 SEK) will be served, as well as other refreshments.
Register for the reception no later than Wednesday 25/10 by sending an e-mail to anita.hoang 'at' chem.lu.se
Find the lecture hall here. Entrance E at Naturvetarvägen 14 will be held open a short time before the lecture for visitors without access-cards.